Live streaming on Altcast.TV is now available!
Latest videos
More available at
https://ugetube.com/@HospitalityReception
https://old.bitchute.com/video/2H0iROqtTRm6/
Invader gas stations lock restrooms for White males who need to piss causing public health crisis!
https://altcast.tv/watch/fake-....swats_mKO6Po43wt121f
Fake Swats!
https://www.cbsnews.com/miami/....news/pregnant-pembro
PEMBROKE PINES — A pregnant woman is behind bars after she allegedly tried to kill her unborn child and her baby's father on Sunday.
Debra Whiteman, 24, was arrested Sunday evening on attempted murder and aggravated battery charges.
According
to an arrest affidavit and press release, Pembroke Pines Police
officers responded to reports of a domestic disturbance at a home in the
area of NW 88th Avenue and NW 8th Street. Upon arrival, the adult
victim told police that he was stabbed by his girlfriend — later
identified as Whiteman.
During the investigation, it was revealed
that the victim and Whiteman had been in a romantic relationship for the
last year and had lived together for the last eight months with other
family members. According to the press release, Whiteman is currently
39-weeks pregnant and that the victim is the baby's father.
Over
the last two to three months, Whiteman allegedly attempted to terminate
her own pregnancy by taking pills, drinking alcohol and punching herself
in the stomach, the press release stated.
https://old.bitchute.com/video/kgF6TJ8QI52q/
NEVER FORGET - THE VACCINATION TENTS!
https://odysee.com/@Publish:6/siegel-invaders:e
"Anti-White" discriminatory racist
invaders posting 1000s of dupe spam miscategorized Florida housing
listings for hotel rooms other invaders rape and murder your abducted
children in on deadly drugs!
Florida Vacation?
When kayaking down the otherworldly
scenic route of the Winter Park Canals, it’s not uncommon to spot
otters, kingfishers, bald eagles, woodpeckers, ospreys, wading birds,
and waterfowl. Birdwatchers particularly enjoy the 5.22-acre public
Kraft Azalea Garden Park, located on the shore of Lake Maitland, as it
is home to many nesting birds during hatchling season.
The Winter Park Chain of Lakes also draws fishing enthusiasts to its 2,781 acres of water. They can expect to catch sunshine bass, striped hybrid bass, bass breams, gar, or tilapia.
Since there is limited public access
for fishing on the shoreline, many opt to use a kayak or canoe to reach
the area’s best fishing holes. The deepest spot of the lakes can be
found in the 29-foot hole on Lake Maitland. Anglers like to come here in
the early morning to catch their fish before the watersports
enthusiasts occupy the lake.
illuminatibot - They knew they would die for saying this on stage. R.I.P. Heroes
Source: https://x.com/iluminatibot/sta....tus/1945664151843754
Comey built a reputation for managing high-profile cases involving sexual exploitation, public corruption, and white-collar crime. Her career highlights include:
Ghislaine Maxwell trial (2021–22): Comey helped secure Maxwell’s conviction on multiple counts related to the sexual exploitation of minors. She had been involved in the Epstein probe from the outset.
Sean "Diddy" Combs trial (2025): Comey prosecuted Combs on sex trafficking and racketeering charges. The jury acquitted him of the most serious counts but convicted him on a lesser prostitution-related charge.
She was also a lead attorney in Epstein-related matters and represented the DOJ in civil litigation seeking to block disclosure of certain investigative records, citing risks of harassment to victims and witnesses.
#justicedepartment #comey #jeffreyepstein
federal prosecutor Maurene Comey, the daughter of former FBI director James Comey, was terminated by the Justice Department. Comey prosecuted Sean “Diddy” Combs and also played a role in the investigation of Jeffrey Epstein and the prosecution and conviction of his co-conspirator Ghislaine Maxwell.
For more context and news coverage of the most important stories of our day, click here: https://www.nbcnews.com
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#justicedepartment #comey #jeffreyepstein
source: https://www.youtube.com/watch?v=rrxDE8izOUc
Thumbnail: https://timesofindia.indiatime....s.com/world/us/expla
Uncommon Sense - Not enough people know that Howard Lutnick was Epstein’s Nextdoor neighbor….
He also didn’t go to work in the twin towers the day of 9/11….
And yes he’s jewish….
Source: https://x.com/Uncommonsince76/....status/1945305389060
Thumbnail: https://gab.com/KeepNHGranite/....posts/11486439035675
The man smiling next to Donald Trump, as Trump tells the media that “only bad people” are interested in the Jeffrey Epstein scandal, is Jewish billionaire and Trump mega-donor Howard Lutnick.
In 1996, Jewish billionaire Leslie Wexner gave his protégé, the Mossad-connected Jewish millionaire Jeffrey Epstein, a $ 13 million dollar townhouse in Manhattan, free of charge.
In 1998, Howard Lutnick purchased the townhouse CONNECTED TO Jeffrey Epstein's townhouse.
Wexner and Lutnick are both major pro-Israel donors, and we all know what country Jeffrey Epstein worked for.
For 21 years, up until Epstein's imprisonment and (apparent) death, Howard Lutnick and Jeffrey Epstein literally shared the same wall between their Manhattan living spaces.
Since February of 2025, Jeffrey Epstein's former next-door-neighbor, Howard Lutnick, has served as the US Secretary of Commerce after being appointed to the position by Donald Trump.
Donald Trump, as we all know, maintained a (well-photographed) personal relationship with Jeffrey Epstein at least through the entirety of the 1990s and into the 2000s.
So why do I point out the fact that, as Trump runs cover for his Mossad-international-child-sex-crime-political-blackmail-agent former friend, the guy standing next to him shared a wall for 21 years with that same former friend?
No reason. Everything's fine. Trust the plan.
https://www.nytimes.com/2024/0....8/10/business/susan-
Aug. 10, 2024
Updated
p.m. ET
Susan Wojcicki, who helped turn Google from a start-up in her garage
into an internet juggernaut, and who became one of Silicon Valley’s most
prominent female executives with her leadership of YouTube, died on
Friday. She was 56. Her death was confirmed by her husband, Dennis
Troper, who wrote on Facebook that she had been living with lung cancer
for two years. He did not say where she died.
https://en.wikipedia.org/wiki/....Jewish_views_on_astr
Astrology has been a topic of debate among Jews for over 2000 years.
https://people.com/marco-trope....r-ssan-wojcicki-son-
The cause of death for Marco Troper, the 19-year-old son of former CEO of YouTube Susan Wojcicki, has been released.
https://www.tinaraymond.com/media
https://www.jacksonville.gov/d....epartments/planning-
According to Florida Statute 455.228, if you hire an unlicensed
contractor, the Department of Business and Professional Regulations (D.
B. P. R.) may issue a cease and desist order. They also may take you to
Circuit Court, which has the authority to impose a civil penalty of up
$5,000 for aiding and abetting unlicensed activity. You could also be
liable for court cost.
If you obtain a permit for an unlicensed contractor, you are held responsible for the work, not the contractor.
If you hire an unlicensed contractor, you may actually pay more for the
job than if you had hired a licensed contractor. Especially if the work
is done incorrectly or never finished, you may have to pay twice or more
for the same job to be corrected or finished.
If the unlicensed contractor fails to pay his sub-contractors or
suppliers, you may be required to pay them even though you have already
paid the contractor.
Plumbing, electrical, and heating and air conditioning work must be done
only by contractors and craftsmen certified in those trades and require
separate permits.
Home improvement contractors must possess a license issued by the State
of Florida as a general, building, or residential contractor.
Roofing contractors are required to be certified or registered by the state.
There is no such thing as a 'legal' jack-of-all-trades.
An 'Occupational License' is not a regulatory license or a Certificate
of Competency, but a tax for the privilege of engaging in or managing a
business, profession, or occupation.
You may be held liable for injury on your property if the unlicensed
contractor has no liability insurance or Worker's Compensation
insurance.
https://www.maennerchor.com/
Location of criminal property management
https://www.apartments.com/810....-2nd-st-n-jacksonvil
810 2nd St N, Jacksonville Beach, FL 32250
jew-spic soyance
Born in Mexico City to a Jewish family, Volkow is a daughter of Esteban
Volkov, whose mother Zinaida Volkova was the eldest daughter of the
Russian communist revolutionary Leon Trotsky.
https://en.m.wikipedia.org/wiki/Nora_Volkow
Volkow's imaging studies of the brains of people addicted to drugs have helped to clarify the mechanisms of drug addiction.[1] At Brookhaven, positron emission tomography (PET) scanning was being used to study the brain in people with schizophrenia.
https://www.newsweek.com/i-joi....ned-gang-neo-nazis-j
The Mexican shot caller would request to wear it when he gambled to
bring him financial luck. This started sort of a buzz in the jail, and
eventually, lots of people were requesting to wear it. Even neo-Nazis
requested to wear it when they were gambling.
https://uarmprotection.com/pro....duct/sa4b-level-iv-b
Unlike traditional solutions, our ballistic plates are designed to
absorb the kinetic kick delivered from a bullet by engulfing the
projectile – simultaneously eliminating ricochet.
https://thepearlrestaurant.com/group-dining/
https://www.msn.com/en-us/news..../us/detroit-dog-atta
A four-year-old boy has been tragically killed by a dog while playing in his grandma's backyard, according to the police.
Lovell Anderson was playing when two pit bulls attacked him, dragging
him under a fence and biting him. The police are investigating the
incident and have taken two dogs into custody. They're trying to figure
out which dog was responsible for the attack. Lovell's aunts said one of
those dogs is their grandmother's pet in Detroit, Michigan.
https://www.jacksonville.gov/d....epartments/neighborh
https://library.municode.com/f....l/jacksonville/codes
https://jaxhumane.org/pet-help..../pet-owner-assistanc
The most recent article: https://www.sctimes.com/story/....news/local/minnesota
AI Overview from Google:
Reports have confirmed that Vance Boelter, the suspect in the shooting deaths of Minnesota Representative Melissa Hortman and her husband, Mark, and the injury of State Senator John Hoffman and his wife, Yvette, possessed writings described as a "manifesto". This document reportedly listed lawmakers and other officials, leading to the belief that the attacks were politically motivated.
The writings were discovered in a vehicle allegedly used by Boelter, which was disguised as a police SUV. Authorities have stated that the document contained a list of individuals, including lawmakers and other public figures, according to People.com and the St. Cloud Times. Some reports indicated that the list also included abortion providers and pro-choice advocates.
Law enforcement has clarified that while the document contained a list of potential targets, it might not be a traditional manifesto explaining his actions in detail. The writings also reportedly contained the phrase "No Kings," which could point to anti-government or anti-establishment motives.
Authorities have alerted those named in the document and provided security as necessary. Boelter has been arrested and faces charges related to the shootings.
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Source: https://m.youtube.com/shorts/WAuz-gpboHY
OG video does not have a description; what follows is from 1000 Year Old Book Found In Turkey Contains A Terrifying Message
The ancient scriptures and bibles that represent the eras of the bible are a highly essential part of history and something that millions of people base their lives on. The majority of these historical and religious works have been lost at various points in time throughout history (mainly due to war). Many of them contained crucial information that has been forgotten or left in the past and is now concealed from Christian society. This is why such objects are highly valuable, especially on the black market, where many of them can be found or stolen from sacred locations. However, none of them are quite as special as this antique bible is. Where does it originate from? What hidden truths about the beginnings of Jesus were covered up? In this video, we bring you an ancient Bible that dates back a thousand years and contains an image of Jesus that will blow your mind!
In 2015, a groundbreaking discovery was made in the Turkish city of Tokat, which has a population of more than 100,000 people. a little town in which people engaged in the illegal trade of historic and ancient things in order to later sell them on the black market. During an operation, law enforcement officers were able to save this bible from the hands of smugglers, which prevented those criminals from destroying other groundbreaking discoveries for investigators all around the world. Right next to the Bible, the authorities discover a massive collection of valuable jewelry as well as over fifty old coins.
More than five billion dollars are thrown away each year as a direct result of the black-market for ancient artefacts. This Bible is not your average edition; rather, it is one of the very first ever produced. It dates back between 101 A.D and 200 A.D. It is still unclear where this bible came from or who penned it, according to the investigators. After hundreds of years of dust building up, the cover was severely destroyed by smugglers. They never provide the ancient treasures with an appropriate setting to care for them, despite the fact that these objects are hard to come by and are fragile. Therefore, once the artefacts have been salvaged, they are in risk of being damaged if they are not properly cared for at a museum. Despite being written in a language that is over 2,000 years old, the Bible nevertheless contains a feature that is instantly recognized to every Christian. a collection of illustrations created with gold leaf, a method that has survived for many years and within which researchers have discovered the remains of various historical personalities. There is a perfect representation of Jesus' face and various illustrations of Mary with descriptions written in Assyrian.
Disclaimer:
The content presented in our videos is intended solely for entertainment purposes. While we may draw upon facts, rumors, and fiction, viewers should not interpret any part of the content as factual or definitive information. Please enjoy responsibly.
Cosmos Lab creates unique transformative content for educational and entertainment purposes and represents the opinions of this channel. We take our content seriously, and all content meets legal standards for licensing or fair use. Any attempts to falsify content strikes via the YouTube copyright system will be dealt with by our legal team.
https://www.youtube.com/watch?v=SHKRZYTctAk
Source: https://rumble.com/v6w2844-100....0-year-old-bible-fou
ARCHIVING
Pizza Pepe 🇺🇸 - Man confronts the child predator who abused him when he was a child.
Make him famous.
Source: https://x.com/RealPizzaPepe/st....atus/194547600537365
TaraBull - The Amish don't vaccinate their children, the results speak for thems...
Source: https://x.com/TaraBull808/stat....us/19454609118602613
Thumbnail: https://x.com/RWMaloneMD/statu....s/193937358382399536
il Donaldo Trumpo - STOP IT!!!🤣🤣🤣
Re-posting the verbiage from HEY COWARDS❗ WE DON'T NEED YOUR EPSTEIN LIST 📝 WE HAVE OUR OWN❗
https://www.frontnieuws.com/wp....-content/uploads/202
https://vault.fbi.gov/jeffrey-epstein
VfB's got your SIX on the flight logs:
https://acrobat.adobe.com/id/u....rn:aaid🇸🇨US:a5f45798
Source: https://x.com/PapiTrumpo/statu....s/194522503767128096
ⁿᵉʷˢ Barron Trump 🇺🇸 - If only people would have listened back then.. he even had the documents showing what the UN agenda is.
They wrote a book about global governance.
Source: https://x.com/BarronTNews_/sta....tus/1945419989164634
Jasper Truth 🇺🇸 - How they calcify the pineal gland
Source: https://x.com/Jasper_Truth/sta....tus/1944997243649437
Thumbnail: https://imgflip.com/i/a0dwgm
A multi pronged attack on every possible attack vector simultaneously ✅
Post Independence Day Publishing House Livestream July 5 2025 Broadcasting From Jacksonville Florida
https://old.bitchute.com/video/m3khBODciIeg/ (Distribution censored)
The Business And Money Behind Cultist Child Rape And Murder 6/25/25 🌻 Livestream From Florida USA!
Looking for housing but they refuse an in-person tour for their advertised unit? Make you give personal information, ID, or even money before the tour? Demand an application fee with deposits? Ask if they are jewish!
The invaders think Alligator Alcatraz is not free housing and they say it only has fences even though it is more free invader housing on our taxes.
Los Angeles Fireworks by Stan.
Had to take another server because Top Pot KBBQ let Nina and others off early, then I got there, and the rush was on!
https://wikiislam.net/wiki/Child_Marriage_in_the_Qur'an
geogroup .com/
https://finance.yahoo.com/quote/GEO/holders/
blackrock .com/corporate
https://cointelegraph.com/lear....n/articles/larry-fin
Born on Nov. 2, 1952, Fink grew up in a Jewish family in Van Nuys, California, where his mother was an English professor and his father owned a shoe store.
https://ia601304.us.archive.or....g/26/items/practical
Instead of destroying the Jews,
Europe reluctantly refined them through this artificial
process of selection and educated them into a leading
nation of the future.
https://judaism.stackexchange.....com/questions/101306
Yes, they are punishable for violating any of these seven mitzvos; none of them are more or less severe than the others. The punishment for each of them is decapitation (Rambam, Hilchos Melachim 9:14).
No warning is needed, but there needs to be at least one male witness and at least one male judge (ibid.). The judge can be either a Jew or a non-Jew (ibid. 10:11).
https://www.alephne.org/templa....tes/articlecco_cdo/a
6 – Do not eat a limb removed from a live animal.
Respect G‑d’s creatures. At first, Man was forbidden to consume meat. After the Great Flood, he was
permitted – but with a warning: Do not cause unnecessary suffering to any creature.
https://www.chabad.org/library..../article_cdo/aid/622
Harness and channel the human libido.
Incest, adultery, and homosexual relations are forbidden.
The family unit is the foundation of human society. Sexuality is the fountain of life and so nothing is more holy than the sexual act. So, too, when abused, nothing can be more debasing and destructive to the human being.
https://www.reuters.com/practi....cal-law-the-journal/
It limited naturalization to “free white persons” of good character who resided in the US for at least two years.
Kalergi predicted in his 1925 book that the future would entail racial and class integration. Believers of the Kalergi plan allege that he wanted Jewish elites to run society and desired the destruction of the white race. Right Wing Watch noted in its report that white nationalist conspiracy websites promote the theory.
https://hopenothate.org.uk/201....9/04/18/exposed-for-
Kalergi Plan
The so-called “Kalergi plan” is an increasingly popular strain of the white genocide conspiracy theory, which alleges that there is a deliberate plan to undermine European white society by a campaign of mass immigration, integration and miscegenation conducted by sinister (and often Jewish) elites.
https://www.researchgate.net/p....ublication/377209425
Intellectuals and scholars debate the implications of the Kalergi
Plan,
European cultures in the face of a more dominant African
influence, as dictated by the sheer demographics and vibrant
cultural expressions from the African continent.
https://greenleaf-sweden.bandc....amp.com/album/revolu
Greenleaf Borlänge, Sweden
https://leginfo.legislature.ca.gov/faces/codes_displaySection.xhtml?lawCode=PEN§ionNum=278.5.
(a) Every person who takes, entices away, keeps, withholds, or conceals a child and maliciously deprives a lawful custodian of a right to custody, or a person of a right to visitation, shall be punished by imprisonment in a county jail not exceeding one year, a fine not exceeding one thousand dollars ($1,000), or both that fine and imprisonment, or by imprisonment pursuant to subdivision (h) of Section 1170 for 16 months, or two or three years, a fine not exceeding ten thousand dollars ($10,000), or both that fine and imprisonment.
(c) A custody order obtained after the taking, enticing away, keeping, withholding, or concealing of a child does not constitute a defense to a crime charged under this section.
More music at
https://newretrowave.bandcamp.....com/album/hotline-su
The Patriot Oasis™ - 🚨BREAKING: Rep. Tim Burchett says whoever is found GUILTY of crimes against children should be HUNG IN PUBLIC.
"If they're found guilty, hang them publicly, I'm over it."
I 100% AGREE WITH THIS!
Source: https://x.com/ThePatriotOasis/....status/1945205702860
TONY - Jon Minadeo aka 'Handsome Truth' calls for the public executıon of White people.
“You will be put on TV and fcking kiIIed.”
Visibility Limited [but not before it got 211.3K views]
This Post may violate X’s rules against Hateful Conduct [but less than zero suspension].
Source: https://x.com/TonyMichaelX/sta....tus/1944949814749213
Thumbnail: https://x.com/TonyMichaelX/sta....tus/1945215562310733
CynicalCracker
@27:30 .. she is a complete noob who should NOT be muddying waters, OR, an agent of distraction, everyone knows tucker wears the kabala bracelet, why is cucker carlson & gavin mcguinness later, even being brought up .....
@29:04 chick talks about cuckled like its a bad thing yet doesnt want people to think she is talking execution/"extermination"....
@30:47 he talks about the nicest thing to do....
32:24 "we dont want this to turn into a violent thing ...."
@39:00 hey distraction agent zach, a growing number of people are realizing America's TYRANNICAL GOVERNMENT needs to be overthrown and we have a second amendment that obligates us to do so without prejudice
Anybody see the CUCKLED vibe being projected? "Not all jews bro.. koombaya!!" <-- This psychopathy is EXACTLY how these parasite jews keep having to get kicked out of countries all the time
stopped watching at the inevitable mocking @40:17 "the jews are getting me with sickness..." giggle giggle teeheehee
FUKING CLOWN DISTRACTORS
···
10 months ago
hankchinaski
The jews declared war on Germany. The jews had their stooge Hitler take power with the jew false flag of the Reichstag fire. The National Zionist signed the Haavara Agreement. The jews had the jews removed from the population centers. Then had the population centers fire bombed killing ten million innocent women and children burnt like charcoal briquettes fused to the asphalt. Hitler with his jew cook jew house keeper and jew doctor throughout the war allowed 338,000 to escape Dunkirk then opened the war on two three thousand mile fronts for the total destruction of Germany as was always intended. We need to deport the invaders and the jews orchestrating the invasion / white genocide AKA the Kalergi Plan. An attack just like the jew attack on 9/11 and the jew attack on the USS Liberty. Just like jew flu was jew media mind fuckery during a mild cold and flu season. Jewish Family Services received a 1.2 billion dollars emergency fund that has no oversight. The JFS has 600 NGOs it works with. So for instance they send money to the Unitarian Universalist in Salt Lake Utah. The UU then has invaders bused to them from the boarder. When the invaders arrive they are feed, given debit cards filled with money and are ask where they would like to go and are given a bus ticket to anywhere in the country.
CynicalCracker
the chick is an idiot and just another "pretty face" that some handler is trying to push out there... the whole "truther community" is one big government created and run military operation to keep the people from overrunning tyrannical governments across the world....
**WARNING**: The "Truther Community" was completely subverted during the 1st purge of 2017-2019, the "Truther Community" is likely ALL Government Agents & Military by now mixed with the noobs
https://www.airforcemag.com/article/1110psyops/
https://mwi.usma.edu/psyop-cyb....er-and-infowar-comba
- "The second challenge involves the velocity and volume of disinformation, propaganda, and threats to cybersecurity in the contemporary information space. The erosion of global borders is inversely proportional to the growth in internet usage. Contemporary life, therefore, has a ubiquitous digital component; increasingly, people around the globe log into a thriving online society that mirrors the physical community. Therefore, cyberspace and its influence have undoubtedly shaped all interactions, up to and including warfare, and technology has increased options for the antagonist as much as it has for the protagonist. Those that 'seize the key terrain of social-media exploitation will have strategic military advantage'.”
- "In his Senate testimony, General Richard Clarke, commander of US Special Operations Command (USSOCOM), advocated for the use of PSYOP forces to address the opportunities and risks of the global information space — a critical domain that challenges the Department of Defense’s command-and-control boundaries. Increasingly, there has been a belief that if 'used preemptively, [online activities] could keep a conflict from evolving in a more lethal direction. As today’s battlefield is dominated by electronic media, the reality is that all future conflict will contain cyber elements at all levels of warfare; regardless of asymmetries in capabilities, usage of cyber components is now part of the battlefield and strategic environment'.”
Content now available at
https://old.bitchute.com/video/SZ1oYAJ8bAUC/
https://ugetube.com/watch/Mv8Db9cxpp1dEAf
This chilling recording from 1967 by Myron C. Fagan uncovers the Illuminati's secret plan to control world events and create a New World Order. Fagan claims to have seen classified documents linking the Illuminati to wars, revolutions, and major historical occurrences. The secret group has been orchestrating global chaos since the 1700s, and this 1967 audio explains their agenda in detail. From the French Revolution to the rise of the CFR, learn how the Illuminati has manipulated the course of history and what it means for the future. Is their control over the world still at play today? Watch now to uncover the shocking truth!
This 1967 Recording Reveals All (Extended Cut)
Thanks for watching!
God Bless you all!!!!
If you like my content and wish to see me continue making videos, please consider supporting ETP, thanks everyone.
Patreon. / endtimesproductions
Paypal - endtimesproductions@protonmail.com
Source: https://youtu.be/DP31WXJyPyE
This comes with a note from YouTube: Illuminati
Wikipedia • The Illuminati is a name given to several groups, both real and fictitious. Historically, the name usually refers to the Bavarian Illuminati, an Enlightenment-era secret society founded on 1 May 1776 in the Electorate of Bavaria.
healthbot - A WEF bioethicist wants to genetically modify humans so they become allergic to meat.
Source: https://x.com/thehealthb0t/sta....tus/1945116130546246
Thumbnail: https://imgflip.com/i/a0c8t8
Couldn't allow that to go unanswered:
He's already allergic to BRAINS 🧠🤣
https://x.com/C_A_N_S_T/status/1945131465596956899
And wouldn't you know it: Alpha-gal Syndrome: When a Tick-Bite Turns to a Meat Allergy
It is widely known that tick bites can lead to a variety of infectious diseases, but did you know that tick bites can also trigger allergic reactions to red meat? Alpha-gal syndrome (AGS) is an allergic disease triggered by the bite of the lone star tick that can lead to severe hypersensitivity reactions and anaphylaxis in patients following exposure to red meat. In recent years, reports of patients with hypersensitivity reactions following the consumption of red meat have been increasing—but why is that?
Knowledge on how to diagnose AGS remains scarce among medical professionals, and treatment options are limited to allergic symptom management. However, a few helpful tools exist when encountering this illness.
Why Is Alpha-gal Syndrome Becoming More Prevalent?
In the U.S., AGS is triggered by the bite of Ambylomma americanum (a.k.a. the lone star tick), which also carries Ehrlichia rickettsia the causitive agent of ehrlichiosis and Rickettsia spp. the causitive agent of Rocky Mountain spotted fever. The lone star tick is the most human-biting tick in the U.S., and it is endemic to many states. A. americanum has expanded its distribution beyond its original range, now reaching the upper midwestern and northeastern regions of the U.S., as well as extending into eastern Canada. Factors like the changing climate play a pivotal role in the increasing geographic range of A. americanum and lead to a growing number of tick bites and associated diseases. Rising temperatures do not only contribute to the ongoing expansion of certain tick species into new geographical areas, but also lengthen their active seasons. This extension may result in changes to host availability, vector numbers, interactions among vectors, and it may alter the prevalence of infections within tick populations.
Outside of the U.S., other tick species have been linked to the development of alpha-gal syndrome and provide increased opportunity for spread. Other species that may be involved with the development of AGS include Ixodes ricinus (Europe), Ixodes holocyclus (Australia), Ixodes cajennense, Ixodes nipponensis, Amblyomma sculptum, Amblyomma variegatum and Haemaphysalis longicornis.
Alpha-gal Pathogenesis
Patients with red meat allergy produce specific IgE antibodies to carbohydrate galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in most mammalian cell membranes. IgE (Immunoglobulin E) antibody production is a response of the immune system to certain allergens. When an individual is exposed to an allergen, which can include foods, dust, pollen and other substances, IgE antibodies specific to that allergen may be produced through the interaction of specific immune cells. Those IgE antibodies then bind to receptors on immune cells, leading to primary sensitization. In the case of AGS, it seems like primary sensitization happens through the tick's saliva. Subsequent exposure to an allergen may then lead to the release of various chemicals, such as histamine or prostaglandins, into surrounding tissues, which causes allergic symptoms. Likewise, patients with AGS experience symptoms after new exposure to the allergenic molecule when eating red meat.
Although, in recent years, reports of AGS are increasing, and research on this topic is of growing interest, alpha-gal is not new. The carbohydrate has been a long-known obstacle for the transplantation of porcine organs into humans. It causes complex biological reactions that activate the complement system, a complex cascade of proteins that act in a coordinated manner to protect the host from pathogens. Ultimately this response results in the destruction of the transplanted organ. Hypersensitivity to alpha-gal is also well described after treatment of patients with therapeutics containing the carbohydrate, for example the monoclonal antibody Cetuximab, which is used to treat advanced bowel cancer and head and neck cancers.
The Role of Tick Saliva in Transmission of AGS and Other Tick-Borne Diseases
Tick saliva is a composition of several hundred molecules, possessing functionalities that extend beyond the simple facilitation of pathogen transfer. Notably, infectious agents, such as bacteria and viruses etc., actively exploit these salivary components to aid disease transmission. Evidence indicates that tick saliva exhibits immunomodulatory properties, suggesting a pivotal role in regulating the complex dynamics inherent to host responses.
Regarding AGS, certain variables have yet to be discerned, as not all individuals exposed to alpha-gal-containing tick saliva subsequently acquire a red meat allergy. Notably, research indicates that ticks engorged with human blood exhibit a considerably heightened production of alpha-gal within their salivary glands compared to those feeding on other mammalian hosts. One study showed significant variability in alpha-gal levels among individual ticks and across diverse geographical locations. This heterogeneity may contribute to the understanding of why not all who are exposed to tick saliva develop AGS. The study also mentioned a noteworthy increase in alpha-gal concentrations within tick salivary glands throughout the duration of the blood meal. While the details of this process remain incompletely understood, the timely removal of ticks during their early feeding stages may potentially mitigate the risk of alpha-gal syndrome. Further investigations are imperative to completely understand the mechanisms at play in primary sensitization and the development of AGS.
Alpha-gal Symptoms
Clinical signs of red meat allergy may range from skin manifestations, such as hives, and abdominal symptoms, like nausea, vomiting, cramps and diarrhea. More severe symptoms may include shortness of breath, swelling of the airways and death.
Symptoms commonly start 3-6 hours after the consumption of red meat, such as pork, beef, lamb and other types of mammalian meats. This late onset is different from other food allergies, where symptoms usually start within the first hour of consumption. In fact, in many cases, after primary sensitization, years of consuming red meat pass before patients experience clinical symptoms.
Alpha-gal Diagnosis
Currently, the most reliable laboratory test for diagnosing AGS is serological testing for alpha-gal-specific IgE antibodies via ImmunoCAP assay. Diagnosis is more likely when positive sIgE (specific IgE antibodies to a certain allergen) antibody levels exceed ≥2 IU/ml or >2% of the patients total IgE level. The total IgE reflects more of a general marker that may be elevated in the case of various immune-related conditions. It is important to mention that the presence of alpha-gal-specific IgE antibodies do not necessarily diagnose the clinical syndrome, though it may be helpful for clinicians to know which patients could possibly develop AGS in the future.
When diagnosing AGS, it is important to consider multiple factors, including clinical presentation, indicative serological results (alpha-gal-specific antibodies, total IgE levels) and risk factors, like tick exposure and geography. It is also important to mention that only a small percentage of patients develop red meat allergy, despite the fact that hundreds of thousands of people get bitten by lone star ticks and may become sensitized to alpha-gal every year.
Alpha-gal Syndrome Treatment and Management
Alpha-gal syndrome is an allergy to mammalian meat.
It is possible to treat allergic symptoms, however there are no direct treatment options available for AGS. Patients with known AGS are advised to carry self-injectable epinephrine and antihistamines. A vital part of AGS management is educating patients on the importance of avoiding additional tick bites because continuous exposure may increase IgE titers to alpha-gal, whereas avoiding being bitten may decrease them over time.
Patients who have this allergy should avoid consuming mammalian products, which can be difficult, as it is not always obvious which products contain mammalian meat. Alpha-gal-carrying proteins can even be found in mammalian milk, and alpha-gal-specific IgE antibodies may recognize alpha-gal in dairy products. While most patients do not experience reactions to dairy products, a small group of affected AGS patients (<10%) receive the suggestion to exclude dairy products from their diets to reduce the risk of allergic reaction.
There have also been reports of AGS patients having allergic reactions after consuming gelatin or tuna contaminated with dolphin meat. Furthermore, patients with AGS should avoid treatment with medication derived from mammals, including monoclonal antibodies, or gelatin-containing medications. Valve replacement with bovine or porcine heart valves may also trigger hypersensitivity reactions and lead to faster decay of the valve. One way around this issue may be to use pig donors in whom the alpha-gal gene has been removed (i.e., alpha-gal knock out pigs).
Still, those who experience an alpha-gal allergy frequently experience symptoms months or even years after cutting out red meat, and while some reach a condition comparable to remission, the symptoms may resurface following new tick bites. For many people, AGS appears to be a long-lasting illness with a severe impact on mental health.
Yet, research shows that a large number of medical professionals in the U.S. are unaware of AGS, and among the health care providers who are familiar with the disease, knowledge about how to diagnose and treat it is limited. Red meat allergy is a topic of ongoing research, and many questions remain unanswered, however progress has been made in recent years to better understand AGS.
In an era of ongoing climatic changes, medical practitioners may have to transcend the boundaries of their regional knowledge pertinent to vector borne diseases in order to better diagnose and treat affected patients.Climate change will necessitate a collaborative vector control and prevention plan. ASM held a Congressional briefing, entitled "The Evolving Threat of Vector Borne Diseases and Harnessing Science to Address It," in July 2022 to advocate for strong federal funding for research and public health efforts to better understand how to address these disease threats.
https://asm.org/articles/2023/....december/alpha-gal-s
Wonder if this was already performed on Plum Island 🤔
https://asm.org/Webinars/Vecto....r-Borne-Disease-in-a
TROGS blew up their scam-op ✅
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